​2-Chlorotritylchloride Resin

2-Chlorotritylchloride Resin
2-Chlorotritylchloride resin is an acid labile resin for Fmoc chemistry. The steric bulk and mild acid
conditions for cleavage make this resin useful in many applications. The steric bulk of the resin prevents
diketopiperazide formation during the attachment of the first two amino acids, a serious problem in the
synthesis of Pro C-terminal and Pro-Xxx C-terminal peptides. Since peptide products can be cleaved
from the resin with very mild acid treatment, 2-chlorotritylchloride resin can be used to prepare protected
peptide fragments for fragment condensation synthesis of large peptides and proteins. This resin is
recommended in cases where racemization of the C-terminal amino acid is a problem because the first
amino acid is attached to the resin without racemization-inducing activation.
2-Chlorotritylchloride resin is moisture sensitive. It must be stored in a tightly sealed container. If the
resin is stored at low temperature, the container must be allowed to warm to room temperature before
opening. Depending on the size of the container and the amount of resin, this could take up to two hours.
For long-term storage, the resin container should be flushed with nitrogen or argon before sealing, then
the resin should be stored at -20°C.