BOP (Castro’s Reagent)

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 BOP (Castro’s Reagent) BOP reagent is a coupling reagent which suppresses racemization during coupling reactions. It is useful in difficult couplings where standard symmetrical acid anhydride and HOBt activated chemistries fail to give good results. This reagent must be used and handled with caution. Hexamethylphsophotriamide (HMPA), a carcinogen, is formed as a by-product when BOP is used. To avoid this hazard, bezotriazole-1-yl-oxy-tris-pyrrolidinophosphonium hexafluorophosphate can be used in place of BOP reagent. Wear safety goggles, chemical resistant gloves, and protective clothing when using BOP reagent. Do not breath the dust from this product. Clean up any spills immediately and dispose of the spilled material in an appropriate chemical waste container.