Ramage Resin

Particle size：100-200mesh

Loading：0.3~1.0mmol/g resin

Cross-linking ： 1%DVB

CAS:68133-55-3

Alternative to the commonly used Rink-resin. The three-circular structure of the Ramage linker prevents fragmentation of the linker during cleavage from the resin followed by back alkylation. A common phenomenon observed during peptide synthesis with the open structure of the Rink-amide linker. Hence, Ramage linker delivers peptides with higher purity and less impurities, than peptides produced with the Rink-amide linker. Ramage resin is particularly recommended for C-terminal Phe, Tyr and Ile. Following Fmoc removal, the resin can be acylated under standard conditions with Fmoc/tBu protocols. Peptide amides can be released from the resin with 50% TFA in DCM or 95% aqueous TFA.